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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/18017

    Title: Altered nitroxidergic and NMDA receptor-mediated modulation of baroreflex-mediated heart rate in obese Zucker rats
    Authors: Chen JS;Wang HJ;Chang WC;Jao CC;Wu BT;Shyu WC;Lee SD
    Contributors: 健康產業管理學系
    Keywords: baroreceptor;blood pressure;glutamate;heart rate;nitric oxide
    Date: 2010-06
    Issue Date: 2012-11-26 12:06:41 (UTC+8)
    Abstract: Arterial baroreflex, an important physiological regulatory system for buffering systemic blood pressure, is impaired in obesity.
    This study investigated whether the blunted baroreflex function in obesity is attributed to the altered nitroxidergic or N-methyl-Daspartate (NMDA) mechanism. Baroreflex bradycardia responses, blood pressure and heart rate in 30 lean and 30 obese
    anesthetized Zucker rats (8–12 weeks of age) were assessed after injecting phenylephrine with intravenous preadministration of
    saline (control), dextromethorphan (DXM, NMDA receptor antagonist, 10 mg kg 1
    ) or N(G)-nitro-L-arginine methyl ester (L-NAME,
    nitric oxide synthase inhibitor, 100 mg kg 1
    ). Compared with lean rats ( 2.00±0.29 b.p.m. mm Hg 1
    ), the baroreflex sensitivity
    (BRS) in obese rats (–0.43±0.05 b.p.m. mm Hg 1) was significantly blunted. The BRS was significantly suppressed by DXM in
    lean rats but not in obese rats. After administration of L-NAME, BRS was significantly suppressed in lean Zucker rats but not in
    obese Zucker rats. The normal BRS was significantly suppressed in lean rats after administration of both DXM and L-NAME, and
    the blunted BRS in obesity was significantly blocked to nearly no BRS after administration of both DXM and L-NAME. This study
    suggests that BRS is blunted in obese rats and that blunted baroreflex is, at least in part, attributed to altered nitroxidergic or
    NMDA receptor-mediated modulation.
    Relation: HYPERTENSION RESEARCH, 33(9):932-936.
    Appears in Collections:[健康產業管理學系] 期刊論文

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