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    Title: Reverse Iontophoresis: A New Approach to Measure Blood Glucose Level
    Authors: Patricia Connolly;Congo Tak-Shing Ching
    Contributors: Bioengineering Unit, University of Strathclyde
    Keywords: reverse iontophoresis;iontophoresismonitoring;non-invasive
    Date: 2007-01
    Issue Date: 2009-10-13 14:58:14 (UTC+8)
    Publisher: Asia University
    Abstract: This study focused on the investigation of the possibility of monitoring blood glucose levels in
    humans by non-invasively extracting glucose and lactate from blood through the skin using reverse
    iontophoresis. In vitro reverse iontophoresis studies have indicated that the optimum switching mode
    for reverse iontophoresis of lactate and glucose are continuous direct current and direct current with
    electrode polarity reversal every 15 minutes, respectively. The application of a current combined with
    electrode polarity reversal every 15 minutes has been suggested for use in humans. The reverse
    iontophoresis technique was applied to 10 healthy volunteers. Glucose and lactate were successfully
    extracted through the subjects’ skin into the methylcellulose gel of the electrodes. A fair-good
    correlation (r2 = 0.62) between the subject’s blood glucose level and the ratio of glucose to lactate
    levels in the collection gels was observed after two outliers were removed from the regression equation.
    The result suggests that it may be possible to non-invasively monitor the blood glucose levels using this
    new approach free of the need for calibration with a blood sample.
    Relation: Asian Journal of Health and Information Sciences 1(4):393-410
    Appears in Collections:[Asian Journal of Health and Information Sciences] v.1 n.4

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