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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/2227


    Title: Genotoxic Pyrrolizidine Alkaloid N-oxides-Mechanism Leading to DNAAdduct Formation and Tumorigenicity
    Authors: Peter. P. Fu;Ming W. Chou;Qingsu Xia;Ya-Chen Yang;Jian Yan;Daniel R. Doerge;Po-Cheun Chan
    Contributors: 保健營養生技學系
    Keywords: LIVESTOCK poisoning plants;PYRROLIZIDINES;ONCOGENIC viruses
    Date: 2001
    Issue Date: 2009-10-29 15:30:42 (UTC+8)
    Abstract: Plants that contain pyrrolizidine alkaloids and pyrrolizidine alkaloid N-oxides are widely distributed in the world. These plants are probably the most common poisonous plants affecting livestock, wildlife, and humans. Although pyrrolizidine alkaloids have been shown to be genotoxic, including tumorigenic in experimental animals, the mechanisms of tumor formation have not been fully understood. Our recent studies on riddelliine, riddelline N-oxide, and dehydroretronecine (DHR) provided evidence suggesting that pyrrolizidine alkaloids and pyrrolizidine alkaloid N-oxides induce tumors via a genotoxic mechanism, and that tumorigenicity is mediated by a set of eight DHR-derived DNA adducts. This mechanism may be general to other carcinogenic pyrrolizidine alkaloids and may also be responsible for the other genotoxicities of pyrrolizidine alkaloids, including mutagenicity and teratogenicity. It is hypothesized that these DHR-derived DNA adducts are potential biomarkers of pyrrolizidine alkaloid tumorigenicity.
    Relation: Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews
    Appears in Collections:[食品營養與保健生技學系] 期刊論文

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