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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/25192

    Title: PARP-2 regulates cell cycle-related genes through histone deacetylation and methylation independently of poly(ADP-ribosyl)ation
    Authors: 梁雅珍;Liang, Ya-Chen;許巧雨;Hsu, Chiao-Yu;姚雅莉;Yao, Ya-Li;楊文明;Yang, Wen-Ming
    Contributors: 生物科技學系
    Date: 2013-02
    Issue Date: 2013-07-11 13:55:06 (UTC+8)
    Abstract: Poly(ADP-ribose) polymerase-2 (PARP-2) catalyzes poly(ADP-ribosyl)ation (PARylation) and regulates numerous nuclear processes, including transcription. Depletion of PARP-2 alters the activity of transcription factors and global gene expression. However, the molecular action of how PARP-2 controls the transcription of target promoters remains unclear. Here we report that PARP-2 possesses transcriptional repression activity independently of its enzymatic activity. PARP-2 interacts and recruits histone deacetylases HDAC5 and HDAC7, and histone methyltransferase G9a to the promoters of cell cycle-related genes, generating repressive chromatin signatures. Our findings propose a novel mechanism of PARP-2 in transcriptional regulation involving specific protein-protein interactions and highlight the importance of PARP-2 in the regulation of cell cycle progression.
    Copyright © 2012 Elsevier Inc. All rights reserved.
    Appears in Collections:[生物科技學系] 期刊論文

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