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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/25219

    Title: Alpinate Oxyphyllae Fructus (Alpinia Oxyphylla Miq) Extracts Inhibit Angiotensin II Induced Cardiac Apoptosis in H9c2 Cardiomyoblast Cells
    Authors: Ch, Yung-Ming;Chang, Yung-Ming;Tsa, Chuan-Te;Tsai, Chuan-Te;Chiun-Chuang;Wang, Chiun-Chuang Roger;Yueh-Sheng, C;Chen, Yueh-Sheng;Lin, Yueh-Min;Lin, Yueh-Min;Kuo, Chia-Hua;Kuo, Chia-Hua;Tza, Bor-Show;Tzang, Bor-Show;Che, Ray-Jade;Chen, Ray-Jade;蔡輔仁;Tsai, Fuu-Jen;黃志揚;HUANG, CHIH-YANG
    Contributors: 生物科技學系
    Date: 2013
    Issue Date: 2013-07-11 13:55:53 (UTC+8)
    Abstract: Angiotensin II (Ang II) is a risk factor for cardiovascular disease. We used a traditional Chinese medicine, alpinate oxyphyllae fructus (AOF), to evaluate its effect on Ang II-induced cardiac apoptosis and mitochondrial dysfunction. Ang II-treated H9c2 cells were administered AOF of 20-100 µg/mL concentrations. Ang II significantly increased TUNEL-positive nuclei in the H9c2 cells, effect was inhibited by AOF administration in both pre-treated and post-treated H9c2 cells. Caspases 9 and 3 activities were increased by Ang II and downregulated by AOF administration, especially in pre-treatment. AOF treatment reversed Ang II-induced mitochondria membrane potential instability in H9c2 cells as observed by JC-1 stain assay. Furthermore, pro-apoptotic proteins Bad and cytochrome c increased and decreased respectively under AOF administration. The levels of p-Bad anti-apoptotic protein were significantly increased after AOF treatment. This study indicates that mitochondrial dependent apoptosis induced by Ang II.
    Appears in Collections:[生物科技學系] 期刊論文

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