 |
English
|
正體中文
|
简体中文
|
Items with full text/Total items : 90453/105672 (86%)
Visitors : 13098187
Online Users : 532
|
|
|
Loading...
|
Please use this identifier to cite or link to this item:
http://asiair.asia.edu.tw/ir/handle/310904400/25219
|
Title: | Alpinate Oxyphyllae Fructus (Alpinia Oxyphylla Miq) Extracts Inhibit Angiotensin II Induced Cardiac Apoptosis in H9c2 Cardiomyoblast Cells |
Authors: | Ch, Yung-Ming;Chang, Yung-Ming;Tsa, Chuan-Te;Tsai, Chuan-Te;Chiun-Chuang;Wang, Chiun-Chuang Roger;Yueh-Sheng, C;Chen, Yueh-Sheng;Lin, Yueh-Min;Lin, Yueh-Min;Kuo, Chia-Hua;Kuo, Chia-Hua;Tza, Bor-Show;Tzang, Bor-Show;Che, Ray-Jade;Chen, Ray-Jade;蔡輔仁;Tsai, Fuu-Jen;黃志揚;HUANG, CHIH-YANG |
Contributors: | 生物科技學系 |
Date: | 2013 |
Issue Date: | 2013-07-11 13:55:53 (UTC+8) |
Abstract: | Angiotensin II (Ang II) is a risk factor for cardiovascular disease. We used a traditional Chinese medicine, alpinate oxyphyllae fructus (AOF), to evaluate its effect on Ang II-induced cardiac apoptosis and mitochondrial dysfunction. Ang II-treated H9c2 cells were administered AOF of 20-100 µg/mL concentrations. Ang II significantly increased TUNEL-positive nuclei in the H9c2 cells, effect was inhibited by AOF administration in both pre-treated and post-treated H9c2 cells. Caspases 9 and 3 activities were increased by Ang II and downregulated by AOF administration, especially in pre-treatment. AOF treatment reversed Ang II-induced mitochondria membrane potential instability in H9c2 cells as observed by JC-1 stain assay. Furthermore, pro-apoptotic proteins Bad and cytochrome c increased and decreased respectively under AOF administration. The levels of p-Bad anti-apoptotic protein were significantly increased after AOF treatment. This study indicates that mitochondrial dependent apoptosis induced by Ang II. |
Relation: | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY,V.77(2):229-234. |
Appears in Collections: | [生物科技學系] 期刊論文
|
Files in This Item:
File |
Size | Format | |
index.html | 0Kb | HTML | 184 | View/Open |
|
All items in ASIAIR are protected by copyright, with all rights reserved.
|