Alpinate Oxyphyllae Fructus (Alpinia Oxyphylla Miq) Extracts Inhibit Angiotensin II Induced Cardiac Apoptosis in H9c2 Cardiomyoblast Cells

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Title:	Alpinate Oxyphyllae Fructus (Alpinia Oxyphylla Miq) Extracts Inhibit Angiotensin II Induced Cardiac Apoptosis in H9c2 Cardiomyoblast Cells
Authors:	Ch, Yung-Ming;Chang, Yung-Ming;Tsa, Chuan-Te;Tsai, Chuan-Te;Chiun-Chuang;Wang, Chiun-Chuang Roger;Yueh-Sheng, C;Chen, Yueh-Sheng;Lin, Yueh-Min;Lin, Yueh-Min;Kuo, Chia-Hua;Kuo, Chia-Hua;Tza, Bor-Show;Tzang, Bor-Show;Che, Ray-Jade;Chen, Ray-Jade;蔡輔仁;Tsai, Fuu-Jen;黃志揚;HUANG, CHIH-YANG
Contributors:	生物科技學系
Date:	2013
Issue Date:	2013-07-11 13:55:53 (UTC+8)
Abstract:	Angiotensin II (Ang II) is a risk factor for cardiovascular disease. We used a traditional Chinese medicine, alpinate oxyphyllae fructus (AOF), to evaluate its effect on Ang II-induced cardiac apoptosis and mitochondrial dysfunction. Ang II-treated H9c2 cells were administered AOF of 20-100 µg/mL concentrations. Ang II significantly increased TUNEL-positive nuclei in the H9c2 cells, effect was inhibited by AOF administration in both pre-treated and post-treated H9c2 cells. Caspases 9 and 3 activities were increased by Ang II and downregulated by AOF administration, especially in pre-treatment. AOF treatment reversed Ang II-induced mitochondria membrane potential instability in H9c2 cells as observed by JC-1 stain assay. Furthermore, pro-apoptotic proteins Bad and cytochrome c increased and decreased respectively under AOF administration. The levels of p-Bad anti-apoptotic protein were significantly increased after AOF treatment. This study indicates that mitochondrial dependent apoptosis induced by Ang II.
Relation:	BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY,V.77(2):229-234.
Appears in Collections:	[生物科技學系] 期刊論文

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