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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/25221

    Title: Herbal Supplement Attenuation of Cardiac Fibrosis in Rats with CCl4-Induced Liver Cirrhosis
    Authors: Hsiao-Chuan;Chang, Hsiao-Chuan;Chi, Yung-Wei;Chiu, Yung-Wei;Lin, Yueh-Min;Lin, Yueh-Min;Che, Ray-Jade;Chen, Ray-Jade;James, A.Lin;James, A.Lin;蔡輔仁;Tsai, Fuu-Jen;蔡長海;郭昱君;Liu, Jer-Yuh;Liu, Jer-Yuh;黃志揚;HUANG, CHIH-YANG
    Contributors: 生物科技學系
    Date: 2013
    Issue Date: 2013-07-11 13:55:57 (UTC+8)
    Abstract: Previously we found carbon tetrachloride (CCl₄) induced cirrhosis associated cardiac hypertrophy and apoptosis. The purpose of this study is to determine whether further CCl₄ treatment would induce cardiac cell fibrosis. The cardiac tissues were analyzed by H&E. histological staining, Trichrome Masson staining and Western blotting. The results showed that the CCl₄-treated-only group exhibits more trichrome staining, meaning that more fibrosis is present. Moreover, CCl₄ could further induce cardiac-fibrosis via TGF-β-p-Smad2/3-CTGF pathway. However, our data showed that the CCl₄- indcued cardiac abnormalities were attenuated by Ocimum gratissimum extract (OGE) and silymarin co- treatments. In conclusion, our results indicated that the OGE and silymarin may be a potential traditional herb for the protection of cardiac tissues from the CCl4 induced cirrhosis associated cardiac fibrosis through modulating the TGF-β signaling pathway.
    Appears in Collections:[生物科技學系] 期刊論文

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