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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/25227

    Title: Dung-shen (Codonopsis pilosula) attenuated the cardiac-impaired insulin-like growth factor II receptor pathway on myocardial cells
    Authors: Tsai, Kun-Hsi;Tsai, Kun-Hsi;Le, Nien-Hung;Lee, Nien-Hung;Ch, Guei-Ying;Chen, Guei-Ying;Hu, Wei-Syun;Hu, Wei-Syun;Ts, Cheng-Yen;Tsai, Cheng-Yen;Chan, Mu-Hsin;Chang, Mu-Hsin;Jon, Gwo-Ping;Jong, Gwo-Ping;Kuo, Chia-Hua;Kuo, Chia-Hua;蔡長海;黃志揚;HUANG, CHIH-YANG
    Contributors: 生物科技學系
    Keywords: Angiotensin II;Apoptosis;Calcium influx;Codonopsis pilosula;Leucine27-insulin like growth factor II;Mitochondrial outer-membrane permeability
    Date: 2013
    Issue Date: 2013-07-11 13:56:08 (UTC+8)
    Abstract: Previous studies from our lab showed that increase in AngII in H9c2 cells causes elevated IGFII and IGFIIR through MEK and JNK, leading to rise in intracellular calcium, calcineurin activation by PLC-β3 via Gαq, insertion into mitochondrial membranes of Bad, and apoptosis via caspases 9 and 3. Codonopsis pilosula is traditionally used to lower blood pressure. The purpose of our study is to investigate if C. pilosula attenuates AngII plus Leu(27)-IGFII-induced calcium influx and apoptosis in H9c2 cardiomyoblasts. C. pilosula significantly attenuated AngII induced IGFIIR promoter activity. Leu(27)-IGFII was applied to enhance the AngII effect. C. pilosula also reversed Ca(2+) influx, MOMP and apoptosis increased by AngII plus Leu(27)-IGFII. Molecular markers in IGFIIR apoptotic pathway (IGFIIR, calcineurin, etc.) and IGFIIR-Gαq association were downregulated by C. pilosula. However, p-Bad(Ser136) and Bcl-2 were increased. Therefore, C. pilosula suppresses AngII plus Leu(27)-IGFII-induced IGFII/IGFIIR pathway in myocardial cells.
    Relation: FOOD CHEMISTRY; 138(2-3):1856-67.
    Appears in Collections:[生物科技學系] 期刊論文

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