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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/25228

    Title: Garlic oil attenuates the cardiac apoptotosis in hamster-fed with hypercholesterol diet
    Authors: Che, Yi-Chang;Cheng, Yi-Chang;Chan, Mu-Hsin;Chang, Mu-Hsin;Cheng-Chih, T;Tsai, Cheng-Chih;Tung-Sheng, C;Chen, Tung-Sheng;范宗宸;Fan, Ming-Jen;Chien-Chung;Lin, Chien-Chung;La, Chao-Hung;Lai, Chao-Hung;蔡輔仁;Tsai, Fuu-Jen;Lin, James A;Lin, James A;黃志揚;HUANG, CHIH-YANG
    Contributors: 生物科技學系
    Keywords: Garlic oil;Hypercholesterolemia;Cardiac apoptosis;Cardiac survival
    Date: 2013
    Issue Date: 2013-07-11 13:56:10 (UTC+8)
    Abstract: Hypercholesterolemia is a well established risk factor for cardiac cell apoptosis. The purpose of this study is to evaluate the effects of garlic oil on cardiac apoptosis induced by a hypercholesterol diet.

    Twenty-four male Golden-Syrian hamsters at 3 months of age were randomly divided into three groups, control, cholesterol and garlic oil groups received a chow diet, chow diet with 2% cholesterol, and chow diet with 2% cholesterol and 1% garlic oil for 8 weeks, respectively.

    The TUNEL-positive apoptotic cells, and several apoptotic proteins were significantly induced in the excised left ventricle in cholesterol group, whereas significant reduction was observed in cholesterol plus garlic oil group. The IGFI receptor dependent survival pathway was inhibited in cholesterol group whereas it was obviously reversed in cholesterol plus garlic oil group. Our results suggest that administration of garlic oil shows protective effects on cardiac apoptosis in rats with high cholesterol intake.
    Relation: FOOD CHEMISTRY, V.136 N.3–4:1296–1302.
    Appears in Collections:[生物科技學系] 期刊論文

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