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    Title: Effect of dehydroepiandrosterone administration on recovery from mix-type exercise training-induced muscle damage
    Authors: Liao, Yi-Hung;Liao, Yi-Hung;Liao, Kun-Fu;Liao, Kun-Fu;Ka, Chung-Lan;Kao, Chung-Lan;Che, Chung-Yu;Chen, Chung-Yu;黃志揚;HUANG, CHIH-YANG;Wei-Hsiang, C;Chang, Wei-Hsiang;John, L.Ivy;John, L.Ivy;Jeffrey, R.B;Jeffrey, R.Bernard;李信達;Lee, Shin-Da;Kuo, Chia-Hua;Kuo, Chia-Hua
    Contributors: 生物科技學系
    Date: 2013-01
    Issue Date: 2013-07-11 13:56:19 (UTC+8)
    Abstract: This study aimed to determine the role of DHEA-S in coping against the exercise training mixing aerobic and resistance components. During 5-day successive exercise training, 16 young male participants (19.2 ± 1.2 years) received either a placebo (flour capsule) or DHEA (100 mg/day) in a double-blinded and placebo-controlled design. Oral DHEA supplementation significantly increased circulating DHEA-S by 2.5-fold, but a protracted drop (~35 %) was observed from Day 3 during training. In the Placebo group, only a minimal DHEA-S reduction (~17 %) was observed. Changes in testosterone followed a similar pattern as DHEA-S. Muscle soreness was elevated significantly on Day 2 for both groups to a similar extent. Lower muscle soreness was observed in the DHEA-supplemented group on Day 3 and Day 6. In the Placebo group, training increased circulating creatine kinase (CK) levels by approximately ninefold, while only a threefold increase was observed in the DHEA-supplemented group. This mix-type exercise training improved glucose tolerance in both groups, while lowering the insulin response to the glucose challenge, but no difference between treatments was observed. Our results suggest that DHEA-S may play a role in protecting skeletal muscle from exercise training-induced muscle damage.
    Appears in Collections:[Department of Biotechnology] Journal Article

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