Dysregulation of MicroRNAs in cancer

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/25245

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题名:	Dysregulation of MicroRNAs in cancer
作者:	Chen, PS;Chen, PS;蘇振良;Su, Jen-Liang;洪明奇;Hung, Mien-Chie
贡献者:	生物科技學系
关键词:	Cancer progression;miRNA biogenesis;miRNA dysregulation
日期:	2013
上传时间:	2013-07-11 13:56:43 (UTC+8)
摘要:	MicroRNAs (miRNAs) are involved in multiple biological activities as well as disease progression including cancer. Interestingly, miRNAs could act as either tumor suppressors or oncogenes depending on the functions of their targets. Using high-throughput profiling, dysregulation of miRNAs has been widely observed in different stages of cancer, and there is mounting evidence demonstrating several misguided mechanisms that cause miRNA dysregulation. In this review, we summarize the key functions of miRNAs in cancer, especially those affecting tumor metastasis and drug resistance. Moreover, the mechanisms leading to dysregulation of miRNAs, including genomic abnormalities, DNA/histone modifications, transcriptional regulation, abnormal biogenesis, and interaction between miRNAs, are also discussed.
關聯:	JOURNAL OF BIOMEDICAL SCIENCE; 19:90.
显示于类别:	[生物科技學系] 期刊論文

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