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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/25247


    Title: Effects of NFKB1 and NFKBIA Gene Polymorphisms on Hepatocellular Carcinoma Susceptibility and Clinicopathological Features
    Authors: Cheng, CW;Cheng, CW;蘇振良;Su, Jen-Liang;Lin, CW;Lin, CW;Su, CW;Su, CW;Shih, CH;Shih, CH;Yang, SF;Yang, SF;Chien, MH;Chien, MH
    Contributors: 生物科技學系
    Date: 2013
    Issue Date: 2013-07-11 13:56:46 (UTC+8)
    Abstract: Background

    Constitutive activation of nuclear factor (NF)-κB is frequently observed in hepatocellular carcinoma (HCC). The current study examined associations of polymorphisms within promoter regions of NFKB1 encoding NF-κB1 and NFKBIA encoding IκBα with the susceptibility of developing HCC and clinicopathological characteristics of the tumors.

    Methodology and Principal Findings

    Genetic polymorphisms of NFKB1 and NFKBIA were analyzed by a real-time polymerase chain reaction (PCR) in 135 HCC patients and 520 healthy controls. The genotypic frequency of the NFKB1 -94 Ins polymorphism in HCC patients was significantly higher than that of the controls (adjusted odds ratio (AOR) = 2.23; 95% confidence interval (CI) 1.32~3.77). No statistical significance was observed for the distribution frequency of the NFKBIA −-519 C/T, -826 C/T, or -881 A/G genotype and haplotype polymorphisms between HCC patients and controls. Furthermore, female HCC patients carrying the NFKB1 -94 Ins polymorphism were associated with lower clinical stages and smaller tumor sizes.

    Conclusions

    Our results indicate that the NFKB1 -94 Ins promoter polymorphism increased the risk of HCC, and may be applied as a predictive factor for the clinical stage and tumor size in female HCC patients.
    Relation: PLoS One
    Appears in Collections:[生物科技學系] 期刊論文

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