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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/3056


    Title: A Novel Feature with Dynamic Time Warping and Least Squares Adjustment for Protein Structure Alignment
    Authors: JEFFREY J. P. TSAI
    Contributors: Department of Computer Science, University of Illinois at Chicago
    Keywords: protein structure alignment;dynamic time warpingleast squares adjustmentcoarse-to-fine matching
    Date: 2006-10
    Issue Date: 2009-11-16 19:33:53 (UTC+8)
    Publisher: Asia University
    Abstract: Protein structure alignment is of importance in protein study. In general, such a task can be
    divided into two categories, i.e., global and local structure alignments. In this paper, one-dimensional features are extracted first from the original protein structures. A hybrid approach combining dynamic time warping and least squares adjustment is proposed for global alignment of protein 3D structures in an iterative fashion, where dynamic time warping is responsible for coarse alignment of two structures and least squares adjustment handles the fine matching of amino acid residues. The residuals of
    matched pairs are utilized to calculate the weights to accelerate the convergence of coarse-to-fine matching. The preliminary results have demonstrated the effectiveness and efficiency of the proposed approach. However, there is still a room for improvement in terms of accuracy and memory usage.
    Relation: Asian Journal of Health and Information Sciences 1(3):261-275
    Appears in Collections:[Asian Journal of Health and Information Sciences] v.1 n.3

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