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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/4570


    Title: Survival of Cancer Cells is Maintained by EGFR Activity
    Authors: Weihua Zhang;Rachel Tsan;Wei-Chien Huang;Qiuyu Wu;Chao-Hua Chiu;Isaiah J. Fidler;Mien-Chie Hung
    Date: 2008-05
    Issue Date: 2009-11-27 13:56:52 (UTC+8)
    Publisher: Asia University
    Abstract: Expression of the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase associated with cell proliferation and survival, is overactive in many tumors of epithelial origin. Blockade of the kinase activity of EGFR has been used for cancer therapy; however, by itself, it does not seem to reach maximum therapeutic efficacy. We report here that in human cancer cells, the function of kinase-independent EGFR is to prevent autophagic cell death by maintaining intracellular glucose level through interaction and stabilization of the sodium/glucose cotransporter 1 (SGLT1).
    Relation: CANCER CELL,13(5):385-393
    Appears in Collections:[生物科技學系] 期刊論文

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