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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/4580

    Title: Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: identification of genes potentially related to epithelial-mesenchymal transition
    Authors: HC Lien;YH Hsiao;YS Lin;YT Yao;HF Juan;WH Kuo;Mien-Chie Hung;KJ Chang;FJ Hsieh
    Keywords: oligonucleotide microarray;metaplastic carcinoma of breast;epithelial?mesenchymal transition
    Date: 2007-07
    Issue Date: 2009-11-27 13:56:55 (UTC+8)
    Publisher: Asia University
    Abstract: Metaplastic carcinoma of the breast (MCB) is a poorly
    understood subtype of breast cancer. It is generally
    characterized by the coexistence of ductal carcinomatous
    and transdifferentiated sarcomatous components, but the
    underlying molecular alterations, possibly related to
    epithelial?mesenchymal transition (EMT), remain elusive.
    We performed transcriptional profiling using half-agenome
    oligonucleotide microarrays to elucidate genetic
    profiles of MCBs and their differences to those of
    ductal carcinoma of breasts (DCBs) using discarded
    specimens of four MCBs and 34 DCBs. Unsupervised
    clustering disclosed distinctive expression profiles between
    MCBs and DCBs. Supervised analysis identified
    gene signatures discriminating MCBs from DCBs and
    between MCB subclasses. Notably, many of the discriminator
    genes were associated with downregulation of
    epithelial phenotypes and with synthesis, remodeling and
    adhesion of extracellular matrix, with some of them have
    known or inferred roles related to EMT. Importantly,
    several of the discriminator genes were upregulated
    in a mutant Snail-transfected MCF7 cell known to
    exhibit features of EMT, thereby indicating a crucial
    role for EMT in the pathogenesis of MCBs. Finally,
    the identification of SPARC and vimentin as poor
    prognostic factors reinforced the role of EMT in cancer
    progression. These data advance our understanding
    of MCB and offer clues to the molecular alterations
    underlying EMT.
    Relation: ONCOGENE (26):7859?7871
    Appears in Collections:[生物科技學系] 期刊論文

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