ASIA unversity:Item 310904400/4580
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 90587/105803 (86%)
造訪人次 : 16865836      線上人數 : 89
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋


    題名: Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: identification of genes potentially related to epithelial-mesenchymal transition
    作者: HC Lien;YH Hsiao;YS Lin;YT Yao;HF Juan;WH Kuo;Mien-Chie Hung;KJ Chang;FJ Hsieh
    關鍵詞: oligonucleotide microarray;metaplastic carcinoma of breast;epithelial?mesenchymal transition
    日期: 2007-07
    上傳時間: 2009-11-27 13:56:55 (UTC+8)
    出版者: Asia University
    摘要: Metaplastic carcinoma of the breast (MCB) is a poorly
    understood subtype of breast cancer. It is generally
    characterized by the coexistence of ductal carcinomatous
    and transdifferentiated sarcomatous components, but the
    underlying molecular alterations, possibly related to
    epithelial?mesenchymal transition (EMT), remain elusive.
    We performed transcriptional profiling using half-agenome
    oligonucleotide microarrays to elucidate genetic
    profiles of MCBs and their differences to those of
    ductal carcinoma of breasts (DCBs) using discarded
    specimens of four MCBs and 34 DCBs. Unsupervised
    clustering disclosed distinctive expression profiles between
    MCBs and DCBs. Supervised analysis identified
    gene signatures discriminating MCBs from DCBs and
    between MCB subclasses. Notably, many of the discriminator
    genes were associated with downregulation of
    epithelial phenotypes and with synthesis, remodeling and
    adhesion of extracellular matrix, with some of them have
    known or inferred roles related to EMT. Importantly,
    several of the discriminator genes were upregulated
    in a mutant Snail-transfected MCF7 cell known to
    exhibit features of EMT, thereby indicating a crucial
    role for EMT in the pathogenesis of MCBs. Finally,
    the identification of SPARC and vimentin as poor
    prognostic factors reinforced the role of EMT in cancer
    progression. These data advance our understanding
    of MCB and offer clues to the molecular alterations
    underlying EMT.
    關聯: ONCOGENE (26):7859?7871
    顯示於類別:[生物科技學系] 期刊論文


    檔案 描述 大小格式瀏覽次數
    310904400-4580.doc34KbMicrosoft Word444檢視/開啟


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋