English  |  正體中文  |  简体中文  |  Items with full text/Total items : 92958/108462 (86%)
Visitors : 20404333      Online Users : 207
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version

    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/4593

    Title: Expression of PEA3 and lack of correlation between PEA3 and HER-2/neu expression in breast cancer
    Authors: Xia, W.;Lien, H-C.;Wang, S.-C;Pan, Y.;Sahin, A.;Kuo, Y-H.;Chang, K-J.;Wang, H.;Yu, Z.;Hortobagyi, G. N.;Shi, D.;Mien-Chie Hung
    Keywords: breast cancer;ETS;HER;2/neu;PEA3;tyrosine kinase receptor
    Date: 2006-04
    Issue Date: 2009-11-27 13:56:59 (UTC+8)
    Publisher: Asia University
    Abstract: The ETS protein PEA3 functions as a transcription factor to regulate gene expression. Although members of the ETS family have been reported to be involved in tumor progression, ectopic expression of PEA3 has been shown to suppress tumor formation. Despite several studies demonstrated frequent expression of PEA3 and its high association with HER-2/neu and have suggested a potential role of PEA3 in breast cancer, contradictory result has shown that the PEA3 was associated with better survival rate in breast cancer. In the current study, we address this discrepancy by examining the expression of PEA3 and HER-2/neu on 289 archived breast cancer tumor tissues and their correlation with clinicopathologic factors and prognosis. The staining of PEA3 was further validated by in situ hybridization for PEA3 mRNA. We found PEA3 was positive in 22.2% (64/289) of all cases and only 25.6% (21/82) of HER-2/neu-overexpressing cases showed co-expression of PEA3. In contrast to HER-2/neu, PEA3 expression was not correlated with prognosis or major clinicopathologic factors, except for a negative correlation with lymphovascular permeation ( p=0.007). This study demonstrates that PEA3 expression is not correlated with HER-2/neu expression in breast cancer tumor tissues, nor is it associated with adverse clinicopathologic factors or prognosis.
    Appears in Collections:[生物科技學系] 期刊論文

    Files in This Item:

    File Description SizeFormat
    310904400-4593 .doc34KbMicrosoft Word460View/Open

    All items in ASIAIR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback