ASIA unversity:Item 310904400/4597
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    题名: The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells
    作者: Jen-Liang Su;Pan-Chyr Yang;Jin-Yuan Shih;Ching-Yao Yang;Lin-Hung Wei;Chang-Yao Hsieh;Chia-Hung Chou;Yung-Ming Jeng;Ming-Yang Wang;King-Jen Chang;Mien-Chie Hung;Kuo, M-L.
    日期: 2006-03
    上传时间: 2009-11-27 13:57:00 (UTC+8)
    出版者: Asia University
    摘要: Flt-4, a VEGF receptor, is activated by its specific ligand, VEGF-C. The resultant signaling pathway promotes angiogenesis and/or lymphangiogenesis. This report provides evidence that the VEGF-C/Flt-4 axis enhances cancer cell mobility and invasiveness and contributes to the promotion of cancer cell metastasis. VEGF-C/Flt-4-mediated invasion and metastasis of cancer cells were found to require upregulation of the neural cell adhesion molecule contactin-1 through activation of the Src-p38 MAPK-C/EBP-dependent pathway. Examination of tumor tissues from various types of cancers revealed high levels of Flt-4 and VEGF-C expression that correlated closely with clinical metastasis and patient survival. The VEGF-C/Flt-4 axis, through upregulation of contactin-1, may regulate the invasive capacity in different types of cancer cells.
    關聯: CANCER CELL 9(3):209-223
    显示于类别:[生物科技學系] 期刊論文


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