English  |  正體中文  |  简体中文  |  Items with full text/Total items : 92958/108462 (86%)
Visitors : 20369019      Online Users : 158
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version

    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/4603

    Title: AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model
    Authors: Chen, I-F.;Ou-Yang, F.;Hung, J-Y.;Liu, J-C.;Wang, H.;Wang, S-C.;Hou, M-F.;Hortobagyi, G. N.;Mien-Chie Hung
    Keywords: AIM2;breast;cancer cancer gene therapy
    Date: 2006
    Issue Date: 2009-11-27 13:57:01 (UTC+8)
    Publisher: Asia University
    Abstract: IFN-inducible proteins are known to mediate IFN-directed antitumor effects. The human IFN-inducible protein absent in melanoma 2 (AIM2) gene encodes a 39-kDa protein, which contains a 200-amino-acid repeat as a signature of HIN-200 family (hematopoietic IFN-inducible nuclear proteins). Although AIM2 is known to inhibit fibroblast cell growth in vitro, its antitumor activity has not been shown. Here, we showed that AIM2 expression suppressed the proliferation and tumorigenicity of human breast cancer cells, and that AIM2 gene therapy inhibited mammary tumor growth in an orthotopic tumor model. We further showed that AIM2 significantly increased sub-G1 phase cell population, indicating that AIM2 could induce tumor cell apoptosis. Moreover, AIM2 expression greatly suppressed nuclear factor-κB transcriptional activity and desensitized tumor necrosis factor-α–mediated nuclear factor-κB activation. Together, these results suggest that AIM2 associates with tumor suppression activity and may serve as a potential therapeutic gene for future development of AIM2-based gene therapy for human breast cancer. [Mol Cancer Ther 2006;5(1):1–7]
    Appears in Collections:[生物科技學系] 期刊論文

    Files in This Item:

    File Description SizeFormat

    All items in ASIAIR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback