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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/4610


    Title: Nuclear interaction of EGFR and STAT3 in the activation of iNOS/NO pathway
    Authors: Lo, H-W;Hsu, S-C.;Ali-Seyed, M.;Gunduz, M.;Xia, W.;Wei, Y.;Bartholomeusz, G.;Shih, J-Y.;Mien-Chie Hung
    Date: 2005
    Issue Date: 2009-11-27 13:57:03 (UTC+8)
    Publisher: Asia University
    Abstract: Epidermal growth factor receptor (EGFR) exists in the nucleus of highly proliferative cells where it functions as a transcription factor. Although EGFR has transactivational activity, it lacks a DNA binding domain and, therefore, may require a DNA binding transcription cofactor for its transcriptional function. Here, we report that EGFR physically interacts with signal transducers and activators of transcription 3 (STAT3) in the nucleus, leading to transcriptional activation of inducible nitric oxide synthase (iNOS). In breast carcinomas, nuclear EGFR positively correlates with iNOS. This study describes a mode of transcriptional control involving cooperated efforts of STAT3 and nuclear EGFR. Our work suggests that the deregulated iNOS/NO pathway may partly contribute to the malignant biology of tumor cells with high levels of nuclear EGFR and STAT3.
    Relation: CANCER CELL 7(6):575-589
    Appears in Collections:[生物科技學系] 期刊論文

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