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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/4625

    Title: Binding at and transactivation of COX-2 promoter by nuclear tyrosine kinase receptor ErbB2
    Authors: Wang, S-C.;Lien, H-C.;Xia, W.;Chen, I-F.;Lo, H-W.;Wang, Z.;Ali-Seyed, M.;Lee, D-F.;Bartholomeusz, G.;Ou-Yang, F.;Giri, D. K.;Mien-Chie Hung
    Date: 2004-09
    Issue Date: 2009-11-27 13:57:07 (UTC+8)
    Publisher: Asia University
    Abstract: Pathological expression of human ErbB-2 protein, also known as HER-2, is common in many types of cancer. ErbB-2 is a member of the EGF receptor tyrosine kinase family and has been rigorously studied as a signaling molecule on the cell membrane. Here, we report that ErbB-2 is also expressed in the nucleus in cultured cells as well as primary tumor tissues. Nuclear ErbB-2 was found to associate with multiple genomic targets in vivo, including the cyclooxygenase enzyme COX-2 gene promoter. ErbB-2 forms a complex at a specific nucleotide sequence of the COX-2 promoter and is able to stimulate its transcription. This study demonstrates the presence of ErbB-2 in the nucleus and identifies the function of ErbB-2 as a transcriptional regulator.
    Relation: CANCER CELL 6(3):251-261
    Appears in Collections:[生物科技學系] 期刊論文

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