English  |  正體中文  |  简体中文  |  Items with full text/Total items : 90120/105278 (86%)
Visitors : 9017752      Online Users : 986
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/4643


    Title: Beta-catenin nuclear localization is associated with grade in ovarian serous carcinoma
    Authors: Lee, C. M.;Shvartsman, H.;Deavers, M. T.;Wang, S.-C.;Xia, W.;Schmandt, R.;Bodurka, D. C.;Atkinson, E. N.;Malpica, A.;Gershenson, D. M.;Mien-Chie Hung;Lu, K. H.
    Keywords: Ovary;Serous tumors;?-Catenin;Pathogenesis
    Date: 2003-03
    Issue Date: 2009-11-27 13:57:12 (UTC+8)
    Publisher: Asia University
    Abstract: Objectives
    ?-Catenin has been previously associated with oncogenic activity in human cancers. We evaluated whether ?-catenin also plays a role in papillary serous ovarian neoplasms.

    Methods
    Immunohistochemistry for ?-catenin was performed on the primary ovarian serous neoplasms of 105 women. Of these, 10 were low malignant potential (LMP) serous tumors, and 95 were serous cancers. Nuclear ?-catenin staining was correlated with grade of tumor and median survival. OVCAR-3, OVCA-420, OVCA-432, and MDAH-277-10c were evaluated for ?-catenin localization and transfected with a T-cell factor (TCF) responsive reporter to evaluate ?-catenin transcriptional activity.

    Results
    Of 105 serous tumors, 13 (12.3%) demonstrated ?-catenin nuclear staining. Eleven of 48 high-grade serous carcinomas (23.0%) demonstrated nuclear staining compared with 1 low-grade serous carcinoma (2.1%) (P = 0.006). One LMP tumor had nuclear staining. ?-Catenin nuclear localization was undetectable in the cell lines tested. Furthermore, transient transfection of the cell lines with a TCF-responsive reporter did not demonstrate significant constitutive transcriptional activation.

    Conclusions
    We found a statistically significant correlation between ?-catenin nuclear localization and ovarian high-grade serous carcinomas. Thus, deregulation of ?-catenin may play a role in the pathogenesis of ovarian high-grade serous carcinomas in contrast to ovarian low-grade serous carcinomas and LMP serous tumors.
    Relation: GYNECOLOGIC ONCOLOGY 88(3):363-368
    Appears in Collections:[生物科技學系] 期刊論文

    Files in This Item:

    File Description SizeFormat
    0KbUnknown249View/Open
    310904400-4643 .doc33KbMicrosoft Word412View/Open


    All items in ASIAIR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback