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    Title: Beta-catenin nuclear localization is associated with grade in ovarian serous carcinoma
    Authors: Lee, C. M.;Shvartsman, H.;Deavers, M. T.;Wang, S.-C.;Xia, W.;Schmandt, R.;Bodurka, D. C.;Atkinson, E. N.;Malpica, A.;Gershenson, D. M.;Mien-Chie Hung;Lu, K. H.
    Keywords: Ovary;Serous tumors;?-Catenin;Pathogenesis
    Date: 2003-03
    Issue Date: 2009-11-27 13:57:12 (UTC+8)
    Publisher: Asia University
    Abstract: Objectives
    ?-Catenin has been previously associated with oncogenic activity in human cancers. We evaluated whether ?-catenin also plays a role in papillary serous ovarian neoplasms.

    Immunohistochemistry for ?-catenin was performed on the primary ovarian serous neoplasms of 105 women. Of these, 10 were low malignant potential (LMP) serous tumors, and 95 were serous cancers. Nuclear ?-catenin staining was correlated with grade of tumor and median survival. OVCAR-3, OVCA-420, OVCA-432, and MDAH-277-10c were evaluated for ?-catenin localization and transfected with a T-cell factor (TCF) responsive reporter to evaluate ?-catenin transcriptional activity.

    Of 105 serous tumors, 13 (12.3%) demonstrated ?-catenin nuclear staining. Eleven of 48 high-grade serous carcinomas (23.0%) demonstrated nuclear staining compared with 1 low-grade serous carcinoma (2.1%) (P = 0.006). One LMP tumor had nuclear staining. ?-Catenin nuclear localization was undetectable in the cell lines tested. Furthermore, transient transfection of the cell lines with a TCF-responsive reporter did not demonstrate significant constitutive transcriptional activation.

    We found a statistically significant correlation between ?-catenin nuclear localization and ovarian high-grade serous carcinomas. Thus, deregulation of ?-catenin may play a role in the pathogenesis of ovarian high-grade serous carcinomas in contrast to ovarian low-grade serous carcinomas and LMP serous tumors.
    Relation: GYNECOLOGIC ONCOLOGY 88(3):363-368
    Appears in Collections:[Department of Biotechnology] Journal Article

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