ASIA unversity:Item 310904400/64326
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 90587/105803 (86%)
造訪人次 : 16745786      線上人數 : 43
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋


    請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/64326


    題名: Andrographis paniculata Extract and Andrographolide Modulate the Hepatic Drug Metabolism System and Plasma Tolbutamide Concentrations in Rats
    作者: Chen, HW;Chen, HW;黃晉修;Huang, Chin-Shiu;Liu, PF;Liu, PF;Li, CC;Li, CC;Chen, CT;Chen, CT;Liu, CT;Liu, CT;Chiang, JR;Chiang, JR;Yao, HT;Yao, HT;李宗貴;Lii, Chong-Kuei
    貢獻者: 保健營養生技學系
    關鍵詞: CONSTITUTIVE ANDROSTANE RECEPTOR;GLUTATHIONE-S-TRANSFERASE;MESSENGER-RNA EXPRESSION;PREGNANE X RECEPTOR;PHASE-II ENZYMES;ACTIVE DITERPENOIDS;SIGNALING PATHWAY;LIVER-MICROSOMES;DIABETIC-RATS;IN-VITRO
    日期: 201308
    上傳時間: 2013-10-29 17:37:32 (UTC+8)
    摘要: Andrographolide is the most abundant terpenoid of A. paniculata which is used in the treatment of diabetes. In this study, we investigated the effects of A. paniculata extract (APE) and andrographolide on the expression of drug-metabolizing enzymes in rat liver and determined whether modulation of these enzymes changed the pharmacokinetics of tolbutamide. Rats were intragastrically dosed with 2 g/kg/day APE or 50 mg/kg/day andrographolide for 5 days before a dose of 20 mg/kg tolbutamide was given. APE and andrographolide reduced the AUC0-12 h of tolbutamide by 37% and 18%, respectively, compared with that in controls. The protein and mRNA levels and enzyme activities of CYP2C6/11, CYP1A1/2, and CYP3A1/2 were increased by APE and andrographolide. To evaluate whether APE or andrographolide affected the hypoglycemic action of tolbutamide, high-fat diet-induced obese mice were used and treated in the same manner as the rats. APE and andrographolide increased CYP2C6/11 expression and decreased plasma tolbutamide levels. In a glucose tolerance test, however, the hypoglycemic effect of tolbutamide was not changed by APE or andrographolide. These results suggest that APE and andrographolide accelerate the metabolism rate of tolbutamide through increased expression and activity of drug-metabolizing enzymes. APE and andrographolide, however, do not impair the hypoglycemic effect of tolbutamide.
    關聯: Evidence-based Complementary and Alternative Medicine, 2013:982689.
    顯示於類別:[食品營養與保健生技學系] 期刊論文

    文件中的檔案:

    檔案 大小格式瀏覽次數
    index.html0KbHTML478檢視/開啟


    在ASIAIR中所有的資料項目都受到原著作權保護.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋