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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/64368


    Title: Si-Wu-tang extract stimulates bone formation through PI3K/Akt/NF-?B signaling pathways in osteoblasts
    Authors: Wu, Chi-Ming;Wu, Chi-Ming;Chen, Po-Chun;Chen, Po-Chun;Li, Te-Mao;Li, Te-Mao;Fong, Yi-Chin;Fong, Yi-Chin;湯智昕;Chih-Hsin, Tang
    Contributors: 生物科技學系
    Keywords: SWT;Osteoblasts;Bone formation;Traditional Chinese medicine
    Date: 201310
    Issue Date: 2013-11-01 09:58:50 (UTC+8)
    Abstract: Background

    Si-Wu-Tang (SWT), a Traditional Chinese Medicine (TCM) formula, is widely used for the treatment of gynopathies diseases such as menstrual discomfort, climacteric syndrome, dysmenorrhea, and other estrogen-related diseases. Recent studies have shown that SWT can treat primary dysmenorrhea, have anti-pruritic anti-inflammatory effects, and protect against radiation-induced bone marrow damage in an animal model. It has been reported that anti-inflammatory and anti-oxidant agents have the potential to treat osteoporosis by increasing bone formation and/or suppressing bone resorption. However, the effect of SWT on bone cell function has not yet been reported.

    Methods

    Alkaline phosphatase (ALP), bone morphogenetic proteins (BMP)-2, and osteopontin (OPN) mRNA expression was analyzed by qPCR. The mechanism of action of SWT extract was investigated using western blotting. The in vivo anti-osteoporotic effect of SWT extract was assessed in ovariectomized mice.

    Results

    Here, we report that SWT increases ALP, BMP-2, and OPN expression as well as bone mineralization. In addition, we show that the PI3K, Akt, and NF-κB signaling pathways may be involved in the SWT-mediated increase in gene expression and bone mineralization. Notably, treatment of mice with SWT extract prevented bone loss induced by ovariectomy in vivo.

    Conclusion

    SWT may be used to stimulate bone formation for the treatment of osteoporosis.
    Relation: BMC Complementary and Alternative Medicine, 13:277.
    Appears in Collections:[生物科技學系] 期刊論文

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