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http://asiair.asia.edu.tw/ir/handle/310904400/64379
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| Title: | Apoptosis signal-regulating kinase 1 is involved in WISP-1–promoted cell motility in human oral squamous cell carcinoma cells |
| Authors: | Ch, Jing-Yuan;Chuang, Jing-Yuan;Chan, An-Chen;Chang, An-Chen;Chian, I-Ping;Chiang, I-Ping;Ts, Ming-Hsui;Tsai, Ming-Hsui;湯智昕;Chih-Hsin, Tang |
| Contributors: | 生物科技學系 |
| Date: | 201310 |
| Issue Date: | 2013-11-01 10:00:03 (UTC+8) |
| Abstract: | Oral squamous cell carcinoma (OSCC) has a tendency to migrate and metastasize. WNT1-inducible signaling pathway protein 1 (WISP-1) is a cysteine-rich protein that belongs to the Cyr61, CTGF, Nov (CCN) family of matrix cellular proteins. The effect of WISP-1 on human OSCC cells, however, is unknown. Here, we showed that WISP-1 increased cell migration and intercellular adhesion molecule-1 (ICAM-1) expression in OSCC cells. Pretreatment of cells with integrin αvβ3 monoclonal antibody (mAb) significantly abolished WISP-1–induced cell migration and ICAM-1 expression. On the other hand, WISP-1–mediated cell motility and ICAM-1 upregulation were attenuated by ASK1, JNK, and p38 inhibitor. Furthermore, WISP-1 also enhanced activator protein 1 (AP-1) activation, and the integrin αvβ3 mAb, and ASK1, JNK, and p38 inhibitors reduced WISP-1–mediated AP-1 activation. Moreover, WISP-1 and ICAM-1 expression correlated with the tumor stage of patients with OSCC. Our results indicate that WISP-1 enhances the migration of OSCC cells by increasing ICAM-1 expression through the αvβ3 integrin receptor and the ASK1, JNK/p38, and AP-1 signal transduction pathways. |
| Relation: | PLoS One, 8(10) |
| Appears in Collections: | [生物科技學系] 期刊論文
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