Dietary trans fats enhance doxorubicin-induced cardiotoxicity in mice

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Title:	Dietary trans fats enhance doxorubicin-induced cardiotoxicity in mice
Authors:	蒙美津;Mong, Mei-Shin;Hsia, Te-Chun;Hsia, Te-Chun;殷梅津;YIN, MEI-CHIN
Contributors:	保健營養生技學系
Keywords:	cardiac injury;coagulation;doxorubicin;MAPK;NF-κB;trans fat
Date:	2013-10
Issue Date:	2013-12-06 14:51:20 (UTC+8)
Abstract:	This study investigated the combined effects of trans fat diet (TFD) and doxorubicin upon cardiac oxidative, inflammatory, and coagulatory stress. TFD increased trans fatty acid deposit in heart (P < 0.05), and decreased protein C and antithrombin-III activities in circulation (P < 0.05). TFD plus doxorubicin treatment elevated activities of plasminogen activator inhibitor-1, lactate dehydrogenase, and creatine phosphokinase (P < 0.05). This combination also raised xanthine oxidase activity, and enhanced cardiac levels of reactive oxygen species, interleukin (IL)-6, IL-10, tumor necrosis factor-alpha, and monocyte chemoattractant protein-1 than TFD or doxorubicin treatment alone (P < 0.05). TFD alone increased cardiac nuclear factor kappa B (NF-κB) activity (P < 0.05), but failed to affect expression of NF-κB and mitogen-activated protein kinase (MAPK) (P > 0.05). Doxorubicin treatment alone augmented cardiac activity, mRNA expression, and protein production of NF-κB and MAPK (P < 0.05). TFD plus doxorubicin treatment further upregulated cardiac expression of NF-κB p65, p-p38, and p-ERK1/2 (P < 0.05). These findings suggest that TFD exacerbates doxorubicin-induced cardiotoxicity.
Relation:	JOURNAL OF FOOD SCIENCE, 78(10):H1621-1628.
Appears in Collections:	[食品營養與保健生技學系] 期刊論文

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