ASIA unversity:Item 310904400/65103
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 90120/105278 (86%)
造訪人次 : 9109320      線上人數 : 507
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋


    請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/65103


    題名: Dietary trans fats enhance doxorubicin-induced cardiotoxicity in mice
    作者: 蒙美津;Mong, Mei-Shin;Hsia, Te-Chun;Hsia, Te-Chun;殷梅津;YIN, MEI-CHIN
    貢獻者: 保健營養生技學系
    關鍵詞: cardiac injury;coagulation;doxorubicin;MAPK;NF-κB;trans fat
    日期: 2013-10
    上傳時間: 2013-12-06 14:51:20 (UTC+8)
    摘要: This study investigated the combined effects of trans fat diet (TFD) and doxorubicin upon cardiac oxidative, inflammatory, and coagulatory stress. TFD increased trans fatty acid deposit in heart (P < 0.05), and decreased protein C and antithrombin-III activities in circulation (P < 0.05). TFD plus doxorubicin treatment elevated activities of plasminogen activator inhibitor-1, lactate dehydrogenase, and creatine phosphokinase (P < 0.05). This combination also raised xanthine oxidase activity, and enhanced cardiac levels of reactive oxygen species, interleukin (IL)-6, IL-10, tumor necrosis factor-alpha, and monocyte chemoattractant protein-1 than TFD or doxorubicin treatment alone (P < 0.05). TFD alone increased cardiac nuclear factor kappa B (NF-κB) activity (P < 0.05), but failed to affect expression of NF-κB and mitogen-activated protein kinase (MAPK) (P > 0.05). Doxorubicin treatment alone augmented cardiac activity, mRNA expression, and protein production of NF-κB and MAPK (P < 0.05). TFD plus doxorubicin treatment further upregulated cardiac expression of NF-κB p65, p-p38, and p-ERK1/2 (P < 0.05). These findings suggest that TFD exacerbates doxorubicin-induced cardiotoxicity.
    關聯: JOURNAL OF FOOD SCIENCE, 78(10):H1621-1628.
    顯示於類別:[食品營養與保健生技學系] 期刊論文

    文件中的檔案:

    沒有與此文件相關的檔案.



    在ASIAIR中所有的資料項目都受到原著作權保護.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋