ASIA unversity:Item 310904400/65105
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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/65105


    Title: One Lignanoid Compound and Four Triterpenoid Compounds with Anti-Inflammatory Activity from the Leaves of Elaeagnus oldhamii Maxim.
    Authors: Liao, Chi-Ren;Liao, Chi-Ren;Ho, Yu-Ling;Ho, Yu-Ling;Guan-Jhong, H;Huang, Guan-Jhong;Chang Syun, Y;Yang, Chang Syun;趙哲毅;Chao, Che-Yi;Yuan-Shiun, C;Chang, Yuan-Shiun;Yueh-Hsiung;Kuo, Yueh-Hsiung
    Contributors: 保健營養生技學系
    Keywords: traditional herbal medicine;Elaeagnus oldhamii Maxim.;lignanoid;triterpenoid;anti-inflammation
    Date: 2013-10
    Issue Date: 2013-12-06 14:51:33 (UTC+8)
    Abstract: One lignanoid compound, isoamericanol B (1), along with four triterpenoid compounds—cis-3-O-p-hydroxycinnamoyloleanolic acid (2), trans-3-O-p-hydroxy cinnamoyloleanolic acid (3), cis-3-O-p-hydroxycinnamoylursolic acid (4), trans-3-O-p-hydroxycinnamoylursolic acid (5) have been isolated for the first time from the leaves of Elaeagnus oldhamii Maxim. Compounds 1–4 significantly inhibited the expression of NO (nitric oxide) produced in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. The IC50 value for inhibition of nitrite production of compound 1 was about 10.3 ± 0.4 μg/mL. In the cell viability test, however, among compounds 1–4 compound 1 did not significantly change cell viability. Therefore, in this study compound 1 possessed anti-inflammatory effects. The result suggests compound 1 as a potential lead compound for the treatment of inflammatory diseases.
    Relation: MOLECULES; 18(11), 13218-13227
    Appears in Collections:[Department of Food Nutrition and Healthy Biotechnology] Journal Article

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