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    题名: One Lignanoid Compound and Four Triterpenoid Compounds with Anti-Inflammatory Activity from the Leaves of Elaeagnus oldhamii Maxim.
    作者: Liao, Chi-Ren;Liao, Chi-Ren;Ho, Yu-Ling;Ho, Yu-Ling;Guan-Jhong, H;Huang, Guan-Jhong;Chang Syun, Y;Yang, Chang Syun;趙哲毅;Chao, Che-Yi;Yuan-Shiun, C;Chang, Yuan-Shiun;Yueh-Hsiung;Kuo, Yueh-Hsiung
    贡献者: 保健營養生技學系
    关键词: traditional herbal medicine;Elaeagnus oldhamii Maxim.;lignanoid;triterpenoid;anti-inflammation
    日期: 2013-10
    上传时间: 2013-12-06 14:51:33 (UTC+8)
    摘要: One lignanoid compound, isoamericanol B (1), along with four triterpenoid compounds—cis-3-O-p-hydroxycinnamoyloleanolic acid (2), trans-3-O-p-hydroxy cinnamoyloleanolic acid (3), cis-3-O-p-hydroxycinnamoylursolic acid (4), trans-3-O-p-hydroxycinnamoylursolic acid (5) have been isolated for the first time from the leaves of Elaeagnus oldhamii Maxim. Compounds 1–4 significantly inhibited the expression of NO (nitric oxide) produced in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. The IC50 value for inhibition of nitrite production of compound 1 was about 10.3 ± 0.4 μg/mL. In the cell viability test, however, among compounds 1–4 compound 1 did not significantly change cell viability. Therefore, in this study compound 1 possessed anti-inflammatory effects. The result suggests compound 1 as a potential lead compound for the treatment of inflammatory diseases.
    關聯: MOLECULES; 18(11), 13218-13227
    显示于类别:[食品營養與保健生技學系] 期刊論文


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