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    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6564

    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/6564

    Title: Monitoring of congenital adrenal hyperplasia by microbore HPLC-electrospray ionization tandem mass spectrometry of dried blood spots
    Authors: Lai,Chien-Chen;Tsai,Fuu-Jen;Wu,Jer-Yuarn;Wei-De Lin;Lee,Chun-Cheng;Chang-Hai Tsai
    Date: 2002-02
    Issue Date: 2009-12-23 14:20:33 (UTC+8)
    Publisher: Asia University
    Abstract: Congenital adrenal hyperplasia (CAH), a disorder caused by a deficiency of the 21-hydroxylase enzyme, is the most common inborn error of the adrenal steroid pathways. Early diagnosis of CAH can be lifesaving, and screening for CAH in newborns by measuring 17-hydroxyprogesterone (17OHP) or other steroids has become a routine part of many programs (1)(2). These steroid hormones have been measured by fluorometry (3)(4), immunoassay (5)(6)(7)(8), and HPLC (4)(9)(10). Most methods are affected by interferences or cross-reactivity with other steroids. Currently, neonatal screening and monitoring for CAH use immunoassays (3)(4). This approach, although practical, lacks specificity because cross-reacting congeners are inseparable from 17OHP in the direct assay.
    Relation: CLINICAL CHEMISTRY 48 (2): 354-356
    Appears in Collections:[醫學暨健康學院] 期刊論文

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