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    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6567


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/6567


    Title: Cytogenetic study of workers exposed to chromium compounds
    Authors: Fang-Yang Wu;Fuu-Jen Tsai;Hsien-Wen Kuo;Chang-Hai Tsai;Wu-Yui Wu;Ruey-Yun Wang;Lai Jim-Shoung
    Date: 2000
    Issue Date: 2009-12-23 14:20:36 (UTC+8)
    Publisher: Asia University
    Abstract: The frequency of sister chromatid exchanges SCEs., high SCE frequency cells HFCs., and genetic polymorphism of
    genotypes glutathione S-transferase GST.M1 and T1 were analyzed in peripheral lymphocytes of 35 workers occupation-
    ally exposed to chromium Cr. and 35 matched control group. Results showed that workers exposed to Cr showed 6.07
    SCErcell, as compared to 4.76 SCErcell for the control group p-0.01.. Smokers showed a statistically significant higher
    frequency of SCE than non-smokers in both groups. The work duration of Cr workers was an important factor. Workers
    exposed for more than 5 years showed a significantly higher level of SCEs p-0.05.. Workers exposed to Cr for 5 or more
    years had higher HFC rates 51.4%.than those exposed for less than 5 years 22.9%., with an odds ratio of 4.5 times than
    those exposed for less than 5 years. In HFC analysis, Cr workers who smoked showed a higher level of HFC 60%.than the
    control group 5.7%.and also had a higher odds ratio 60.4.compared with the control group. Among non-smokers, the
    odds ratio was 9.0. Another objective of this study is to investigate the relationship between SCE and genetic polymorphisms of GST M1 and T1 in Cr workers. The results showed that the incidence of GSTM1 null genotype was 60% in the control group and 77.1% in Cr workers, and percentages of GSTT1 deletion were 42.9% and 62.9% in control and exposed individuals, respectively. There was a slightly increased frequency of SCE among Cr workers with GSTM1 null genotype as opposed to non-null genotype individuals. A similar result was seen among the control group; however, there were no statistically significant differences. In conclusion, the current study found the positive induction of SCE in workers who smoked orrand were exposed to Cr. However, different GST genotypes did not influence the level of cytogenetic damage between groups. Despite slight variation in numbers, they all appear to be not different. q2000 Elsevier Science B.V. All rights reserved.
    Relation: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (464): 289-296
    Appears in Collections:[醫學暨健康學院] 期刊論文

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