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    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6576

    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/6576

    Title: Rapid screening assay of trimethylaminuria in urine with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
    Authors: Wei-Yi Hsu;Wan-Yu Lo;Chien-Chen Lai;Fuu-Jen Tsai;Chang-Hai Tsai;Yuhsin Tsai;Wei-De Lin;Mei-Chyn Chao
    Date: 2007-05
    Issue Date: 2009-12-23 14:20:41 (UTC+8)
    Publisher: Asia University
    Abstract: Trimethyamine (TMA) and trimethylamine N-oxide (TMAO) are the most important urine parameters for diagnosing and monitoring trimethylaminuria. A rapid, simple, and specific method based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) was developed to determine the presence of TMA and TMAO in urine samples from patients with trimethylaminuria. Formation of the quaternary tetramethylamino iodide by derivatization of TMA with methyl iodide allows measurement of TMA by MALDI-TOFMS. The method is repeatable and reproducible, with coefficients of variance (CVs) <3%. This new method was used for direct determination of TMA and TMAO in urine specimens obtained from normal children and patients. The proposed method allows for rapid and reliable measurements of TMA and TMAO in urine specimens from patients affected by trimethylaminuria.
    Appears in Collections:[醫學暨健康學院] 期刊論文

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