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    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6579


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/6579


    Title: Interleukin-1β gene polymorphisms in Taiwanese patients with gout
    Authors: Man-Ling Chen;Chung-Ming Huang;Chang-Hai Tsai;Fuu-Jen Tsai
    Date: 2005
    Issue Date: 2009-12-23 14:20:43 (UTC+8)
    Publisher: Asia University
    Abstract: The purpose of this study was to examine whether interleukin-1 beta (IL-1) promoter and exon 5 gene polymorphisms are markers of susceptibility or clinical manifestations in Taiwanese patients with gout. The study included 196 patients in addition to 103 unrelated healthy control subjects living in central Taiwan. From genomic DNA, polymorphisms of the gene for IL-1 promoter and IL-1 exon 5 were typed. Allelic frequencies were compared between the two groups, and the relationship between allelic frequencies and clinical manifestations of gout was evaluated. No significant differences were observed in the allelic frequencies of the IL-1 promoter between patients with gout and healthy control subjects. Additionally, we did not detect any association of the IL-1 promoter genotype with the clinical and laboratory profiles of gout patients. However, there was a significant difference between the two groups in terms of hypertriglyceridemia (P=0.0004, 2=12.52, OR 7.14, 95%CI 0.012–0.22). There was also a significant difference in the genotype of IL-1 exon 5 polymorphism between patients with and without hypertriglyceridemia. Results of the present study suggest that polymorphisms of the IL-1 promoter and IL-1 exon 5 are not related to gout patients in central Taiwan.
    Relation: RHEUMATOLOGY INTERNATIONAL 25 (3): 179-182
    Appears in Collections:[醫學暨健康學院] 期刊論文

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