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    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6584


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/6584


    Title: Collagen type 3 alpha 1 polymorphism and risk of pelvic organ prolapse
    Authors: Huey-Yi Chen;Ya-Wen Chung;Wei-Yong Lin;Jiunn-Chin Wang;Fuu-Jen Tsai;Chang-Hai Tsai
    Date: 2008-10
    Issue Date: 2009-12-23 14:20:45 (UTC+8)
    Publisher: Asia University
    Abstract: Objective
    To investigate whether pelvic organ prolapse (POP) is associated with collagen 3 alpha 1 (COL3A1) polymorphisms and other factors.
    Methods
    A case-control association study was conducted with 84 women affected with POP and 147 controls. The genotypes of nucleotides COL3A1 rs1800255 and COL3A1 rs1801184 polymorphisms were ascertained by polymerase chain reaction and restriction fragment length polymorphism analysis.
    Results
    The distribution of the COL3A1 rs1800255 genotypes was significantly different among affected women and controls. Older age and incidence of COL3A1 rs1800255 genotype AA were significantly associated with risk of POP.
    Conclusion
    There may be an association between COL3A1 genotype and risk of POP.
    Relation: INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS 103 (1): 55-58
    Appears in Collections:[醫學暨健康學院] 期刊論文

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