English  |  正體中文  |  简体中文  |  Items with full text/Total items : 90069/105176 (86%)
Visitors : 6564154      Online Users : 169
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6585


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/6585


    Title: Estrogen receptor alpha polymorphism is associated with pelvic organ prolapse risk
    Authors: Huey-Yi Chen;Ya-Wen Chung;Wei-Yong Lin;Chen Wen-Chi;Fuu-Jen Tsai;Chang-Hai Tsai
    Date: 2008-08
    Issue Date: 2009-12-23 14:20:46 (UTC+8)
    Publisher: Asia University
    Abstract: Estrogen and estrogen receptors are known to play important roles in the pathophysiology of pelvic organ prolapse (POP). We investigated whether estrogen receptor α (ERα) gene polymorphisms were associated with POP risk by conducting a case-control association study in 88 women with POP and 153 women without POP. Genotypes of the ERα (ESR1) gene polymorphisms (rs17847075, rs2207647, rs2234693, rs3798577, and rs2228480) were determined by polymerase chain reaction, followed by restriction fragment length polymorphism analysis. There was significant difference between women with and those without POP in the distribution of the ESR1 rs2228480 genotypes evaluated. By using multivariable logistic regression, age and ESR1 rs2228480 genotype GA were significantly associated with POP risk. Although the sample size of women with POP studied is small, the present study shows that ERα genotype may be associated with POP risk.
    Relation: INTERNATIONAL UROGYNECOLOGY JOURNAL 19 (8): 1159-1163
    Appears in Collections:[醫學暨健康學院] 期刊論文

    Files in This Item:

    File SizeFormat
    0KbUnknown448View/Open


    All items in ASIAIR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback