ASIA unversity:Item 310904400/6585
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    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6585


    题名: Estrogen receptor alpha polymorphism is associated with pelvic organ prolapse risk
    作者: Huey-Yi Chen;Ya-Wen Chung;Wei-Yong Lin;Chen Wen-Chi;Fuu-Jen Tsai;Chang-Hai Tsai
    日期: 2008-08
    上传时间: 2009-12-23 14:20:46 (UTC+8)
    出版者: Asia University
    摘要: Estrogen and estrogen receptors are known to play important roles in the pathophysiology of pelvic organ prolapse (POP). We investigated whether estrogen receptor α (ERα) gene polymorphisms were associated with POP risk by conducting a case-control association study in 88 women with POP and 153 women without POP. Genotypes of the ERα (ESR1) gene polymorphisms (rs17847075, rs2207647, rs2234693, rs3798577, and rs2228480) were determined by polymerase chain reaction, followed by restriction fragment length polymorphism analysis. There was significant difference between women with and those without POP in the distribution of the ESR1 rs2228480 genotypes evaluated. By using multivariable logistic regression, age and ESR1 rs2228480 genotype GA were significantly associated with POP risk. Although the sample size of women with POP studied is small, the present study shows that ERα genotype may be associated with POP risk.
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