English  |  正體中文  |  简体中文  |  Items with full text/Total items : 93288/109022 (86%)
Visitors : 670329      Online Users : 399
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6592

    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/6592

    Title: A codon 31 ser-arg polymorphism of the WAF-1/CIP-1/p21/tumor suppressor gene in Chinese primary open angle glaucoma
    Authors: Tsai,Fuu-Jen;Hui-Ju Lin;Chang-Hai Tsai;Chen,Wen-Chi;Tsai SH;Tsai san-chang
    Date: 2004
    Issue Date: 2009-12-23 14:20:49 (UTC+8)
    Publisher: Asia University
    Abstract: Purpose: Glaucomatous neuropathy is a type of cell death by apoptosis. Apoptosis is a genetically controlled form of cell death, and one of its primary regulatory steps is the activation of the tumour suppressor protein p53, of which p21 is an effector protein. The association between p21 codon 31 polymorphism and primary open-angle glaucoma (POAG) patients was evaluated in this study. Methods: The study included 58 POAG patients and a control group of 59 healthy volunteers. Polymerase chain reaction-based analysis was used to resolve the p21 codon 31 polymorphism. Results: The genotype frequencies of p21 codon 31 polymorphism were statistically different (p <0.05) between the two groups. The Arg allele of the p21 codon 31 polymorphism was more frequently found in POAG patients than in healthy individuals (odds ratio: 2.389, 95% confidence interval: 1.14-5.01). Conclusion: This study suggests that an association exists between the Arg allele of the p21 codon 31 polymorphism and POAG in the Chinese population.
    Appears in Collections:[醫學暨健康學院] 期刊論文

    Files in This Item:

    File SizeFormat

    All items in ASIAIR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback