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    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6595

    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/6595

    Title: HLA-E Gene Polymorphism Associated with Kawasaki Disease Susceptibility and Formation of Coronary Artery Aneurysms
    Authors: Ying-Ju Lin;Lei Wan;Wu,Jer-Yuarn;Jinn-Chyuan Sheu;Lin Cheng Wen;Yu-Ching Lan;Chih-Ho Lai;CH Hung;Yuhsin Tsai;Chang-Hai Tsai;Ting-Hsu Lin;Jaung-Geng Lin;Kai-Chung Hsueh;Yu-Min Huang;Jeng-Sheng Chang;Fuu-Jen Tsai
    Date: 2009-02
    Issue Date: 2009-12-23 14:20:51 (UTC+8)
    Publisher: Asia University
    Abstract: Objective. Kawasaki disease (KD) is a pediatric systemic vasculitis of unknown cause for which a genetic influence is supposed. The purpose of this study was to identify possible genetic variants in the major histocompatibility complex (MHC) region that are associated with KD and the development of coronary artery aneurysms (CAAs) in a Taiwanese population.
    Methods. The 168 genetic variants covering the MHC locus were analyzed in an association study of a Taiwanese cohort of 93 KD patients and 680 unrelated healthy children matched for sex and age with the study patients.
    Results. Eleven single-nucleotide polymorphisms (SNPs) were associated with the occurrence of KD. The SNP located at the 3 -untranslated region of HLA–E (rs2844724) was highly associated (P < 1 10 7). In addition, the frequency of the C allele was higher in KD patients without CAAs than in controls (P < 0.001) due to a significantly increased frequency of the CC and CT genotypes. Plasma levels of soluble HLA–E were significantly higher in KD patients than in controls regardless of the presence of CAAs. Furthermore, there was a trend toward higher plasma levels of soluble HLA–E in
    KD patients with the CT and TT genotypes of the HLA–E gene polymorphism.
    Conclusion. Our results suggest that the HLA–E gene polymorphism may play a role in the pathogenesis of KD.
    Relation: ARTHRITIS AND RHEUMATISM 60 (2): 604-610
    Appears in Collections:[醫學暨健康學院] 期刊論文

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