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    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6600

    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/6600

    Title: G/T polymorphism in the interleukin-2 exon 1 region among Han Chinese systemic lupus erythematosus patients in Taiwan
    Authors: Ying-Ju Lin;Lei Wan;Jinn-Chyuan Sheu;Chung-Ming Huang;Lin Cheng Wen;Yu-Ching Lan;Chih-Ho Lai;Chien-Hui Hung;Yuhsin Tsai;Chang-Hai Tsai;Wei-Yong Lin;Hsin-Ping Liu;Ting-Hsu Lin;Yu-Min Huang;Fuu-Jen Tsai
    Date: 2008-09
    Issue Date: 2009-12-23 14:20:53 (UTC+8)
    Publisher: Asia University
    Abstract: Abstract Interleukin-2 (IL-2), one of the crucial immunoregulatory cytokines required for T lymphocyte activation, plays an important role in autoimmune diseases. An IL-2 genetic G/T polymorphism (rs2069763) has been linked with multiple sclerosis and rheumatoid arthritis. We tested a hypothesis that this polymorphism confers systemic lupus erythematosus (SLE) susceptibility. Study participants were Han Chinese SLE patients and a healthy control group in Taiwan. Our results indicate (a) a significantly higher G allele frequency in SLE patients (P=1.91×10?14; OR=3.94; 95% CI=2.74–5.66), (b) a significantly higher G allele frequency in SLE patients with antinuclear antibodies (ANA) (P=0.033; OR=4.21; 95% CI=1.01–17.51) and (c) a significantly lower G allele frequency in SLE patients with discoid rash (P=0.019; OR=0.41; 95% CI=0.19–0.88). Our results suggest that this polymorphism may be involved in the genetic background of Taiwanese SLE.
    Relation: CLINICAL IMMUNOLOGY 129 (1): 36-39
    Appears in Collections:[醫學暨健康學院] 期刊論文

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