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    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6611

    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/6611

    Title: Amino acid concentrations in cerebrospinal fluid in children with acute lymphoblastic leukemia undergoing chemotherapy
    Authors: Ching-Tien Peng;Kang-His Wu;Shou-Jen Lan;JJ Tsai;Fuu-Jen Tsai;Chang-Hai Tsai
    Date: 2005-04
    Issue Date: 2009-12-23 14:20:58 (UTC+8)
    Publisher: Asia University
    Abstract: Cerebrospinal fluid (CSF) amino acid concentrations were measured in 45 children with acute lymphoblastic leukemia (ALL). Central nervous system (CNS) disease was absent in 34 and present in 11 (Groups L and M, respectively) at diagnosis. Thirty-two otherwise healthy children with febrile convulsions were studied for comparison. Results from this study show that glutamine levels at Day 0 were significantly higher in patients than in controls. Patients in Group M had elevated glutamine levels compared to Group L. In comparison, at Day 14, concentrations of glutamine and asparagine decreased, while glutamic acid amounts increased significantly in Group L. Glutamine levels fell at Day 42 in Group M, which may have resulted from more intensive treatment. From this study we hypothesise that higher baseline glutamine levels are indicative of a greater risk for CNS leukemia. Large-scale prospective trials are required to confirm increased baseline CSF glutamine levels in ALL patients, to identify glutamine as a marker for CNS disease and to clarify underlying mechanisms regulating glutamine in ALL.
    Relation: EUROPEAN JOURNAL OF CANCER (41): 1158-1163
    Appears in Collections:[醫學暨健康學院] 期刊論文

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