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    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6645


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/6645


    Title: Relation of polymorphism in the region of human osteocalcin gene to bone mineral density and occurrence of osteoporosis in postmenopausal Chinese women in Taiwan
    Authors: Huey-Yi Chen;Tsai HD;Chen Wen-Chi;Wu,Jer-Yuarn;Fuu-Jen Tsai;Chang-Hai Tsai
    Date: 2001
    Issue Date: 2009-12-23 14:21:14 (UTC+8)
    Publisher: Asia University
    Abstract: Osteoporosis is a common disorder with a strong genetic component. Our aim was to evaluate the correlation of the HindIII osteocalcin gene polymorphism to bone mineral density (BMD) and their relationship to osteoporosis. We determined the HindIII osteocalcin gene polymorphism using polymerase chain reaction (PCR)-based restriction analysis in postmenopausal Chinese women in Taiwan. The osteocalcin gene polymorphism was detected by the restriction enzyme HindIII, where the H allele indicated the absence of the cuttable site and the h allele indicated its presence. We then related the genotypes to BMD and occurrence of osteoporosis in these women. The allelic frequencies for postmenopausal Chinese women in Taiwan were 64% for h and 36% for H in HindIII restriction fragment length polymorphisms. The prevalence of each genotype in the study population was 37.7% hh, 52.6% Hh, and 9.7% HH. The subjects with genotype hh had the greatest BMD at the lumbar spine and the femoral neck, and those with HH had the smallest BMD at the femoral neck, but these differences did not reach statistical significance. The HindIII osteocalcin genotype showed a significant effect on the prevalence of osteoporosis in the subjects at the femoral neck, that is, women with genotype HH had a 6.4 times greater risk for osteoporosis (P < 0.05), and those with genotype Hh had a 1.2 times greater risk than women with genotype hh. In conclusion, the HindIII osteocalcin gene polymorphism is associated with reduced BMD and predisposes women to osteoporosis at the femoral neck.
    Relation: JOURNAL OF CLINICAL LABORATORY ANALYSIS (40): 143-150
    Appears in Collections:[醫學暨健康學院] 期刊論文

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