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    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6651

    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/6651

    Title: Complement factor H variant increases the risk for early age-related macular degeneration
    Authors: Lin Jane-Ming;Yi-Yu Tsai;Lei Wan;Hui-Ju Lin;Chang-Hai Tsai;Fuu-Jen Tsai;Shuen-hui Tseng
    Date: 2008-11
    Issue Date: 2009-12-23 14:21:17 (UTC+8)
    Publisher: Asia University
    Abstract: Purpose: To investigate whether a polymorphism in the complement factor H gene determines the risk for the development of early age-related macular degeneration (AMD).
    Methods: In this retrospective case-control study, we enrolled 133 unrelated Taiwan Chinese patients with early AMD and 180 age- and sex-matched control subjects. Early AMD was defined as the presence of extensive intermediate drusen or any large, soft drusen (?125 μm), possibly accompanied by drusenoid retinal pigment epithelial detachment, and the absence of signs of late AMD. Genomic DNA was extracted from peripheral blood obtained from all the AMD patients and control subjects. Polymerase chain reaction was performed to analyze the complement factor H polymorphism (Y402H, rs1061170).
    Results: The genotype distribution differed significantly between the early AMD patients (TT 80%; TC 14%; and CC 6%) and controls (TT 91%; TC 9%; CC 0%; P = 9 × 10-4). The C allele frequency was significantly higher in the early AMD patients than in the controls (13% vs. 4%, P = 1 × 10-4, odds ratios = 3.26, 95% confidence intervals = 1.76-6.02).
    Conclusions: Our study demonstrated that the presence of the Y402H polymorphism in complement factor H is significantly associated with increased susceptibility to early AMD in Taiwan Chinese populations and that the C allele frequency is low in these populations.
    Appears in Collections:[醫學暨健康學院] 期刊論文

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