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    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6657


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/6657


    Title: Interleukin-1 receptor antagonist gene polymorphism in Taiwanese patients with gout
    Authors: Sui-Foon Lo;Chung-Ming Huang;Chang-Hai Tsai;Man-Ling Chen;Fuu-Jen Tsai
    Date: 2005
    Issue Date: 2009-12-23 14:21:19 (UTC+8)
    Publisher: Asia University
    Abstract: The purpose of this study was to examine whether interleukin-1 receptor antagonist (IL-1Ra) gene polymorphism is a marker of susceptibility to or of the clinical characteristics of gout in Taiwanese patients. METHODS: 196 Taiwanese patients with gout and 103 unrelated normal healthy control subjects living in central Taiwan were studied. Polymorphism of the gene for IL-1Ra was typed from genomic DNA. Allelic frequencies and carriage rates were compared between gout patients and control subjects. The relationship between IL-1Ra genotypes and the clinical characteristics of gout was also evaluated. RESULTS: No significant differences were observed in genetic and allelic frequencies of the IL-1Ra gene polymorphism between patients with gout and healthy control subjects. Furthermore, we did not detect any association of IL-1Ra genotype with the clinical and laboratory profiles in patients with gout. CONCLUSION: The results from the present study suggest that the interleukin-1 receptor antagonistgene polymorphism is not a genetic marker of susceptibility to gout for Taiwanese. Furthermore, our study also suggests that the IL-1Ra gene polymorphism is unrelated to the clinical characteristics of gout.
    Relation: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 23 (1): 85-88
    Appears in Collections:[醫學暨健康學院] 期刊論文

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