ASIA unversity:Item 310904400/6658
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 90429/105609 (86%)
造访人次 : 10283551      在线人数 : 75
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻
    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6658


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/6658


    题名: Association of GABRG2 Polymorphisms with Idiopathic Generalized Epilepsy
    作者: I-Ching Chou;Lee,Chun-Cheng;Chang-Hai Tsai;Yuhsin Tsai;Lei Wan;Yu-An Hsu;Tsai-Chung Li;Tsai,Fuu-Jen
    日期: 2007-01
    上传时间: 2009-12-23 14:21:20 (UTC+8)
    出版者: Asia University
    摘要: Missense mutations in the γ2 subunit of γ-aminobutyric acid (GABA) receptor gene have recently been described in families with idiopathic generalized epilepsies. This study aimed to evaluate whether polymorphisms of the γ2 subunit of the GABA receptor gene are associated with idiopathic generalized epilepsies. A total of 77 children with idiopathic generalized epilepsies and 83 normal control subjects were included in the study. Polymerase chain reaction was used to identify the C/T and A/G polymorphisms of the γ2 subunit of the GABA receptor gene on chromosome 5q33. Genotypes and allelic frequencies in both groups were compared. The γ2 subunit of the GABA receptor (nucleotide position 3145 in intron G-> A) gene in both groups was not significantly different. In contrast, the γ2 subunit of GABA receptor (SNP211037)-C allele frequency in patients with idiopathic generalized epilepsies was significantly higher than that in healthy control subjects (P = 0.002). The odds ratio for developing idiopathic generalized epilepsies in individuals with the γ2 subunit of the GABA receptor (SNP211037)-C/C genotype was 3.61 compared with individuals with the γ2 subunit of the GABA receptor (SNP211037)-T/T genotype. These data suggest that the γ2 subunit of the GABA receptor gene might be one of the susceptibility factors for idiopathic generalized epilepsies.
    關聯: PEDIATRIC NEUROLOGY 36 (1): 40-44
    显示于类别:[醫學暨健康學院] 期刊論文

    文件中的档案:

    档案 大小格式浏览次数
    0KbUnknown510检视/开启


    在ASIAIR中所有的数据项都受到原著作权保护.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈