ASIA unversity:Item 310904400/6658
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 90437/105768 (86%)
造訪人次 : 10943222      線上人數 : 615
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6658


    請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/6658


    題名: Association of GABRG2 Polymorphisms with Idiopathic Generalized Epilepsy
    作者: I-Ching Chou;Lee,Chun-Cheng;Chang-Hai Tsai;Yuhsin Tsai;Lei Wan;Yu-An Hsu;Tsai-Chung Li;Tsai,Fuu-Jen
    日期: 2007-01
    上傳時間: 2009-12-23 14:21:20 (UTC+8)
    出版者: Asia University
    摘要: Missense mutations in the γ2 subunit of γ-aminobutyric acid (GABA) receptor gene have recently been described in families with idiopathic generalized epilepsies. This study aimed to evaluate whether polymorphisms of the γ2 subunit of the GABA receptor gene are associated with idiopathic generalized epilepsies. A total of 77 children with idiopathic generalized epilepsies and 83 normal control subjects were included in the study. Polymerase chain reaction was used to identify the C/T and A/G polymorphisms of the γ2 subunit of the GABA receptor gene on chromosome 5q33. Genotypes and allelic frequencies in both groups were compared. The γ2 subunit of the GABA receptor (nucleotide position 3145 in intron G-> A) gene in both groups was not significantly different. In contrast, the γ2 subunit of GABA receptor (SNP211037)-C allele frequency in patients with idiopathic generalized epilepsies was significantly higher than that in healthy control subjects (P = 0.002). The odds ratio for developing idiopathic generalized epilepsies in individuals with the γ2 subunit of the GABA receptor (SNP211037)-C/C genotype was 3.61 compared with individuals with the γ2 subunit of the GABA receptor (SNP211037)-T/T genotype. These data suggest that the γ2 subunit of the GABA receptor gene might be one of the susceptibility factors for idiopathic generalized epilepsies.
    關聯: PEDIATRIC NEUROLOGY 36 (1): 40-44
    顯示於類別:[醫學暨健康學院] 期刊論文

    文件中的檔案:

    檔案 大小格式瀏覽次數
    0KbUnknown513檢視/開啟


    在ASIAIR中所有的資料項目都受到原著作權保護.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋