ASIA unversity:Item 310904400/6672
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 90429/105609 (86%)
Visitors : 10453203      Online Users : 815
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version

    Please use this identifier to cite or link to this item:

    Title: Association Between Vitamin-D Receptor Gene FokI Polymorphism and Graves'Disease Among Taiwanese Chinese
    Authors: Rong-Hsing Chen;Chwen-Tzuei Chang;Huey-Yi Chen;CHEN W.G.;Chang-Hai Tsai;Fuu-Jen Tsai
    Date: 2007-05
    Issue Date: 2009-12-23 14:21:26 (UTC+8)
    Publisher: Asia University
    Abstract: 1,25(OH)2D3, exerting its biological effects through the vitamin-D receptor (VDR), plays a role in the modulation of the human immune system. The aim of this study was to test for the presence of an association between VDR gene polymorphism and the susceptibility to Graves' disease (GD) for Taiwanese Chinese. Using a polymerase chain reaction (PCR)-based restriction analysis, we screened the VDR exon 2 start codon T/C (VDR-FokI) polymorphism to determine the genotypes for 88 GD patients and 90 normal controls. From the genotype analysis, GD patients featured a greater proportion of the CC genotype (44.3%) and a smaller proportion of the TT genotype (12.5%) than was the case for normal controls (CC: 23.3% and TT: 28.9%; chi-squared test, P=0.003). The odds ratios (ORs) for the risk of the CC genotype's appearance compared with the corresponding values for the TT and TC genotypes, for the GD patient group, were, 4.39 (95% confidence interval [CI]: 1.82-10.61) and 2.10 (95% CI: 1.06-4.18), respectively. With respect to the allelic analysis, we observed significantly increased C-allele (65.9%) and decreased T-allele (34.1%) frequencies among GD patients compared to normal controls (C: 47.2% and T: 52.8%; chi-squared test, P=0.002). The OR for the risk of appearance of the C allele in the GD-patient group was 1.93 (95% CI: 1.27-2.95). In conclusion, the VDR-FokI T/C polymorphism might be able to be used as a genetic marker to predict the likelihood of GD development.
    Appears in Collections:[College of Medical and Health Science] Journal Article

    Files in This Item:

    File SizeFormat

    All items in ASIAIR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback