ASIA unversity:Item 310904400/6685
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 90570/105786 (86%)
造访人次 : 16305671      在线人数 : 262
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻
    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6685


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/6685


    题名: Anti-SARS coronavirus 3C-like protease effects of Isatis indifotica root and plant-derived phenolic compounds
    作者: Cheng-Wen Lin;Tsai,Fuu-Jen;Chang-Hai Tsai;Chien-Chen Lai;Lei Wan;Tin-Yun Ho
    日期: 2005-10
    上传时间: 2009-12-23 14:21:32 (UTC+8)
    出版者: Asia University
    摘要: The 3C-like protease (3CLpro) of SARS-coronavirus mediates the proteolytic processing of replicase polypeptides 1a and 1ab into functional proteins, becoming an important target for the drug development. In this study, Isatis indigotica root extract, five major compounds of I. indigotica root, and seven plant-derived phenolic compounds were tested for anti-SARS-CoV 3CLpro effects using cell-free and cell-based cleavage assays. Cleavage assays with the 3CLpro demonstrated that IC50 values were in micromolar ranges for I. indigotica root extract, indigo, sinigrin, aloe emodin and hesperetin. Sinigrin (IC50: 217 M) was more efficient in blocking the cleavage processing of the 3CLpro than indigo (IC50: 752 M) and beta-sitosterol (IC50: 1210 M) in the cell-based assay. Only two phenolic compounds aloe emodin and hesperetin
    dose-dependently inhibited cleavage activity of the 3CLpro, in which the IC50 was 366 M for aloe emodin and 8.3 M for hesperetin in the cell-based assay.
    關聯: ANTIVIRAL RESEARCH 68 (1): 36-42
    显示于类别:[醫學暨健康學院] 期刊論文

    文件中的档案:

    档案 大小格式浏览次数
    0KbUnknown571检视/开启


    在ASIAIR中所有的数据项都受到原著作权保护.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈