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    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6696

    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/6696

    Title: Implantation of olfactory ensheathing cells promotes neuroplasticity in murine models of stroke
    Authors: Woei-Cherng Shyu;Demeral David Liu;Shinn-Zong Lin;Wen-Wen Li;Cing-Yun Su;Ying-Chen Chang;Hsiao-Jung Wang;Hsing-Won Wang;Chang-Hai Tsai;Hung-Li
    Date: 2008-07
    Issue Date: 2009-12-23 14:21:37 (UTC+8)
    Publisher: Asia University
    Abstract: Murine olfactory ensheathing cells (OECs) promote central nervous system axonal regeneration in models of spinal cord injury. We investigated whether OECs could induce a neuroplastic effect to improve the neurological dysfunction caused by hypoxic/ischemic stress. In this study, human OECs/olfactory nerve fibroblasts (hOECs/ONFs) specifically secreted trophic factors including stromal cell–derived factor–1α (SDF-1α). Rats with intracerebral hOEC/ONF implantation showed more improvement on behavioral measures of neurological deficit following stroke than control rats. [18F]fluoro-2-deoxyglucose PET (FDG-PET) showed increased glucose metabolic activity in the hOEC/ONF-treated group compared with controls. In mice, transplanted hOECs/ONFs and endogenous homing stem cells including intrinsic neural progenitor cells and bone marrow stem cells colocalized with specific neural and vascular markers, indicating stem cell fusion. Both hOECs/ONFs and endogenous homing stem cells enhanced neuroplasticity in the rat and mouse ischemic brain. Upregulation of SDF-1α and CXCR4 in hOECs/ONFs promoted neurite outgrowth of cocultured primary cortical neurons under oxygen glucose deprivation conditions and in stroke animals through upregulation of cellular prion protein (PrPC) expression. Therefore, the upregulation of SDF-1α and the enhancement of CXCR4 and PrPC interaction induced by hOEC/ONF implantation mediated neuroplastic signals in response to hypoxia and ischemia.
    Relation: JOURNAL OF CLINICAL INVESTIGATION 118 (7): 2482-2495
    Appears in Collections:[醫學暨健康學院] 期刊論文

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