ASIA unversity:Item 310904400/6701
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    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6701


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    题名: Prognostic Significance of the Proline Form of p53 Codon 72 Polymorphism in Nasopharyngeal Carcinoma
    作者: Ming-Hsui Tsai;Chia-Der Lin;Hsieh YY;Chang FC;Fuu-Jen Tsai;Chen Wen-Chi;Chang-Hai Tsai
    日期: 2002
    上传时间: 2009-12-23 14:21:40 (UTC+8)
    出版者: Asia University
    摘要: Objectives/ Hypothesis An important tumor suppressor gene, p53, plays a role in the regulation of cell progression and prevention of carcinogenesis. Mutated p53 is related to cell progression and malignancy. We aimed to evaluate the association between nasopharyngeal carcinoma and p53 polymorphism. Study Design Case control study.
    Methods All individuals were divided into two groups: nasopharyngeal carcinoma (n = 50) and non-nasopharyngeal carcinoma groups (n = 59). Their p53 codon 72 polymorphisms (arginine [Arg] homozygotes, heterozygotes, proline [Pro] homozygotes) were detected by polymerase chain reaction. Associations between nasopharyngeal carcinoma and p53 polymorphism were evaluated.
    Results Distributions of various p53 polymorphisms significantly differed between the two groups. We noted a dominant presentation of Pro homozygotes in the nasopharyngeal carcinoma population over that in the non-nasopharyngeal carcinoma population. Proportions of Pro homozygotes and heterozygotes and Arg homozygotes were 32%, 28%, and 40% in the nasopharyngeal carcinoma population and were 13.5%, 44.1%, and 42.4% in the non-nasopharyngeal carcinoma population, respectively.
    Conclusions An association exists between nasopharyngeal carcinoma and p53 codon 72 polymorphism. The p53 Pro homozygotes are to a higher risk of development of nasopharyngeal carcinoma.
    關聯: LARYNGOSCOPE 112 (1): 116-119
    显示于类别:[醫學暨健康學院] 期刊論文

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