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    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6702


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/6702


    Title: An Interleukin-4 Gene but Not Interleukin-1 Beta Gene Polymorphism Is Associated with Oral Cancer
    Authors: Tsai,Ming-Hsui;Chen,Wen-Chi;Chang-Hai Tsai;Hang Liang-wen;Tsai,Fuu-Jen
    Date: 2005-03
    Issue Date: 2009-12-23 14:21:40 (UTC+8)
    Publisher: Asia University
    Abstract: We aimed to evaluate whether polymorphisms of the interleukin-4 (IL-4) gene promoter and intron 3 regions, and polymorphisms of the IL-1 beta gene promoter and exon 5 regions are associated with oral cancer. This study included 130 patients with oral cancer and 105 age-matched healthy controls who lived in the same area as the patients. Each genetic polymorphism was typed by polymerase chain reaction (PCR)-based restriction analysis. We then compared the genotype distribution and allelic frequencies of each polymorphism between the oral cancer patients and the controls. The CC homozygote genotype of the IL-4 gene promoter -590 region differed significantly between the patients with oral cancer and the controls (odds ratio (OR)=6.0, 95% confidence interval (CI)=1.2-30.7, chi-square test, P=0.044). No significant difference in either the genotype distribution or the allelic frequencies of the IL-1 beta gene polymorphisms was observed between patients with oral cancer and controls. The IL-4 gene -590 C/T polymorphism is associated with oral cancer and is a suitable genetic marker for screening for oral cancer. However, whether the -590 C/T polymorphism of the IL4 gene plays a role in oral cancer remains unclear. Further substantiation based on larger patient samples is needed.
    Relation: JOURNAL OF CLINICAL LABORATORY ANALYSIS 19 (3): 93-98
    Appears in Collections:[醫學暨健康學院] 期刊論文

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